Теофилин при астма и ХОББ

Theophylline   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE VOL 188 2013   Theophylline (dimethylxanthine) has been used to treat airway diseases for more than 80 years. It was originally used as a bronchodilator, but the relatively high doses required are associated with frequent side effects, so its use declined as inhaled b2-agonists became / прочети повече

Утвърдена и експериментална медикаментозна терапия на белодробна саркоидоза

Established and experimental medical therapy of pulmonary sarcoidosis   Eur Respir J 2013; 41: 1424–1438   ABSTRACT: The treatment options for pulmonary sarcoidosis have increased over the past 10 years. As new treatments have been introduced, the best way to assess and compare treatments remains unknown. The goal of this review is to discuss the / прочети повече

Pulmonary Necrotizing Granulomas of Unknown Cause

CHEST 2013; 144(3):813–824   Clinical and Pathologic Analysis of 131 Patients With Completely Resected Nodules   Background: The cause of pulmonary necrotizing granulomas is often unclear, even after histologic examination. Our aim was to determine the clinical signifi cance of histologically unexplained necrotizing granulomas. Methods: Pulmonary necrotizing granulomas surgically resected at the Mayo Clinic (1994-2004) / прочети повече

Резултати от национално скринингово проучване върху рак на белия дроб

Results of the Two Incidence Screenings in the National Lung Screening Trial   T h e new engl and journa l o f medicine n engl j med 369;10 nejm.org 920 september 5, 2013   Background The National Lung Screening Trial was conducted to determine whether three an- nual screenings (rounds T0, T1, and T2) / прочети повече

Продължително макролидно лечение при хронично белодробно заболяване

Long-term macrolide treatment for chronic respiratory disease   Eur Respir J 2013; 42: 239–251 | DOI: 10.1183/09031936.00136712   Long-term macrolide treatment was first shown to alter the natural history of diffuse panbronchiolitis (DPB) in the late 1980s. Since then, macrolides have been demonstrated to exert antiinflammatory and immunomodulatory activity in addition to being antimicrobial. Indeed, / прочети повече

Phosphodiesterase-4 Inhibitor Therapy for Lung Diseases

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE VOL 188 2013   Bianca Beghe` 1,  Klaus F. Rabe2,3,  and  Leonardo  M. Fabbri1   1Section of Respiratory Diseases, Department of Oncology, Haematology, and Respiratory Diseases, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy; 2Department of Pulmonology, Christian Albrechts University Kiel, member of the / прочети повече

A Rare Case of Empyema

CHEST 2013; 144 ( 1 ): 350 – 353   An 85-year-old man presented  to an outside hospi- tal with 2 weeks of progressive vague chest discomfort and worsening shortness of breath. Upon presentation  he was septic, with fever, tachypnea, and tachycardia. Chest radiograph showed a large sponta- neous left-sided pneumothorax with a large pleural / прочети повече

Възможности за използване на медицинска марихуана – резултати от гласуване сред медици

Medicinal Use of Marijuana — Polling Results Jonathan N. Adler, M.D., and James A. Colbert, M.D.   The New England Journal of Medicine n engl j med 368;22 nejm.org may 30, 2013   Readers recently joined in a lively debate about the use of medicinal marijuana. In Clinical Decisions, 1 an interactive feature in which / прочети повече

b2-Agonist Therapy in Lung Disease

Терапия с β2-агонисти – възможности при бронхообструктивни белодробни болести

β2-Agonist Therapy in Lung  Disease AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE VOL 187 2013 Mario Cazzola1,2, Clive P. Page3, Paola Rogliani1, and  M. Gabriella Matera4   1Department of System Medicine, University of Rome Tor Vergata, Rome, Italy; 2Department of Pulmonary Rehabilitation, San Raffaele Pisana Hospital, IRCCS, Rome, Italy; 3Sackler Institute of Pulmonary Pharmacology, / прочети повече

Кортикостероиди при астма и ХОББ

Inhaled Corticosteroids in Lung  Diseases   Hengameh H. Raissy1, H. William Kelly1, Michelle Harkins2, and Stanley J. Szefler3,4,5,6   1Department of Pediatrics and 2Department of Internal Medicine, School of Medicine, University of New Mexico, Albuquerque, New Mexico; 3Division of Pediatric Clinical Pharmacology and 4Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, Denver, / прочети повече